Thermo Fisher Scientific IP3 Receptor 1 Polyclonal Antibody
IP3 Receptor 1에 특이적인 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에서 반응합니다. Western blot, IHC, ICC 등 다양한 연구 응용에 적합하며, ER 내 칼슘 신호 및 세포 사멸 연구에 활용됩니다. -20°C 보관, PBS buffer 및 sodium azide 포함.
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Thermo Fisher Scientific IP3 Receptor 1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | View 2 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | – | View 1 publication |
| Immunocytochemistry (ICC/IF) | – | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues N(1829) K K K D D E V D R D A P S R K K A K E(1848) of human IP3 Receptor Type I |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Whole serum, PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2129982 |
Product Specific Information
PA3-901A detects inositol 1,4,5-triphosphate receptor type-I (IP3R-I) from mouse, human, and rat tissues.
This antibody has been successfully used in Western blot procedures, detecting a ~240–260 kDa protein representing IP3R-I from rat and mouse brain extracts.
PA3-901A is a remanufactured lot of PA3-901, previously used in Western blot, immunoprecipitation, and immunohistochemistry.
The immunogen sequence is 100% conserved across human, mouse, and rat IP3R-I proteins. The corresponding peptide (Cat. # PEP-019) is available for neutralization and control experiments.
Target Information
IP3 Receptor 1 is an intracellular channel mediating calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate.
It regulates epithelial secretion of electrolytes and fluid through interaction with AHCYL1 and plays a role in ER stress-induced apoptosis.
Cytoplasmic calcium released from the ER triggers apoptosis via CaM kinase II activation, leading to downstream apoptotic pathways.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
- PA3-901A_IP3_Receptor_1_Q14643-1_Rabbit.svg
- PA3-901A_IP3_Receptor_1_Q14643-1_Rabbit_PDP.jpeg
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