Thermo Fisher Scientific Lass6 Polyclonal Antibody

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
WLPHNVTWADL KNTEEATFPQ AEDL

Highest antigen sequence identity to the following orthologs:

• Mouse: 100%
• Rat: 100%

Target Information

Longevity assurance genes (LAGs) represent a subgroup of the homeobox gene family. Five mammalian homologs have been reported, and the corresponding proteins have been investigated for their role in ceramide synthesis. Members of the LAG family are involved in cell growth regulation and cancer differentiation.

LASS6 may participate in sphingolipid synthesis or its regulation. It interacts with ATP6V0C, ASGR1, ASGR2, and SLC22A1/OCT1. Localized to the nuclear membrane as a multi-pass membrane protein, possibly expressed on the endoplasmic reticulum membrane. Glycosylation on Asn-18 is not necessary for function.

Like other LAG family members, the LASS6 protein contains a homeodomain and LAG1 domain. Lass6 displays highest homology to LASS5. The gene is localized to human chromosome 2q24.3, spanning a large genomic region of 318 kb. Sequences in mouse and zebrafish suggest conservation of LASS6 in vertebrates. LASS6 is broadly expressed across tissues and may play a role in cancer differentiation and early embryonic development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.