Thermo Fisher Scientific B4GALT4 Polyclonal Antibody

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
LQRMKISRPLP EVGKYTMVFH TRDKGNEVNA ERMKLLHQVS RVWRTDGLSS CSYKLVSVEH NPLYINITVD FWFGA

Highest antigen sequence identity to the following orthologs:

• Mouse: 80%
• Rat: 80%

Target Information

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins with exclusive specificity for the donor substrate UDP-galactose, transferring galactose in a beta1,4 linkage to acceptor sugars (GlcNAc, Glc, and Xyl).
Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence directing the protein to the Golgi apparatus, which remains uncleaved to function as a transmembrane anchor.
By sequence similarity, the beta4GalTs form four groups:

• beta4GalT1 and beta4GalT2
• beta4GalT3 and beta4GalT4
• beta4GalT5 and beta4GalT6
• beta4GalT7

The enzyme encoded by this gene mainly plays a role in glycolipid biosynthesis. Two alternatively spliced transcript variants have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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