Thermo Fisher Scientific CD19 Monoclonal Antibody (MB19-1), PE, eBioscience
마우스 CD19 단백질을 인식하는 MB19-1 단클론 항체로, PE 형광 표지되어 있습니다. Flow Cytometry에 최적화되어 있으며, B 세포 표면 발현 분석에 사용됩니다. 4°C 암소 보관, 동결 금지. 연구용 전용 제품입니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | 1 publication |
| Flow Cytometry (Flow) | 0.5 µg/test | 15 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Mouse / IgA, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MB19-1 |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_465577 |
Additional Available Formats
- APC (Cat. 17-0191-82)
- Biotin (Cat. 13-0191-82)
- FITC (Cat. 11-0191-82)
- Functional Grade (Cat. 16-0191-85)
- Custom conjugation available upon request
Product Specific Information
Description:
The MB19-1 monoclonal antibody reacts with mouse CD19, a 95 kDa transmembrane glycoprotein expressed on B cells throughout development except plasma cells. Follicular dendritic cells also express CD19. Together with CD21, CD81, and MHC class II, CD19 forms a complex associated with the BCR. Signaling through CD19 induces tyrosine phosphorylation, calcium flux, and B cell proliferation. Staining with MB19-1 is typically dimmer than with rat anti-mouse CD19 clone 6D5.
Applications Reported:
Reported for use in flow cytometric analysis.
Applications Tested:
Tested by flow cytometric analysis of mouse splenocytes. Recommended ≤0.5 µg per test (100 µL final volume). Optimal titration recommended.
Excitation: 488–561 nm; Emission: 578 nm; Compatible with Blue, Green, and Yellow-Green lasers.
Filtered at 0.2 µm post-manufacturing.
Target Information
CD19 is a member of the immunoglobulin superfamily with two Ig-like domains. It is expressed on all peripheral B cells and certain myeloid leukemia cells. CD19 acts as a key regulator of B cell activation and proliferation, forming part of the B cell receptor (BCR) complex. It lowers the activation threshold for antigen receptor signaling and can also signal independently. Mutations in CD19 can cause hypogammaglobulinemia, while overexpression leads to B cell hyperactivity.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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