Thermo Fisher Scientific Angiotensinogen Recombinant Rabbit Monoclonal Antibody (SD201-02)
Recombinant rabbit monoclonal antibody against human Angiotensinogen. Validated for WB and ICC/IF. Offers high specificity, lot-to-lot consistency, and animal origin-free formulation. Suitable for research use in hypertension and cardiovascular studies.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SD201-02 |
| Immunogen | Recombinant protein Human Angiotensinogen (aa 361–485) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809653 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned, and individual clones are screened to select the best candidates for production.
Advantages include:
- High specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broad immunoreactivity due to the large rabbit immune repertoire
Target Information
The AGT gene encodes pre-angiotensinogen (angiotensinogen precursor), which is expressed in the liver and cleaved by renin in response to lowered blood pressure. The resulting angiotensin I is further processed by angiotensin converting enzyme (ACE) to produce angiotensin II, a key regulator of blood pressure.
Mutations in AGT are linked to essential hypertension, renal tubular dysgenesis, structural atrial fibrillation, and inflammatory bowel disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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