Thermo Fisher Scientific HLA-E Monoclonal Antibody (MEM-E/07)

Applications and Tested Dilution

Product Specifications

Additional Formats

• Biotin
• Request custom conjugation

Product Specific Information

This antibody reacts with some classical MHC Class I molecules (MHC Class Ia):

• HLA-B7 (strongly)
• HLA-B8 (moderately)
• HLA-B27, -B44 (weakly)

Target Information

HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons:

1. Exon 1 encodes the leader peptide
2. Exons 2 and 3 encode the alpha1 and alpha2 domains (peptide-binding regions)
3. Exon 4 encodes the alpha3 domain
4. Exon 5 encodes the transmembrane region
5. Exons 6 and 7 encode the cytoplasmic tail

HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem mass spectrometry.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.