Thermo Fisher Scientific NOXA Recombinant Rabbit Monoclonal Antibody (JA30-03)
Recombinant rabbit monoclonal antibody recognizing human NOXA. Validated for WB, IHC(P), and Flow Cytometry. Offers high specificity, lot-to-lot consistency, and animal origin-free formulation. Suitable for apoptosis and p53 pathway research.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:8,000 |
| Flow Cytometry (Flow) | 1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JA30-03 |
| Immunogen | Synthetic peptide within Human Noxa (aa 5–54) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809956 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and expressed, and individual clones are screened to select the best candidates for production.
Advantages include:
- High specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to the larger rabbit immune repertoire
Target Information
Apoptosis is associated with various diseases and developmental processes. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of genes such as p53R2, p53AIP1, and PUMA.
Noxa, a p53 target gene, encodes a BH3-only proapoptotic protein. Both Noxa and PUMA are transcriptional targets of p53. X-ray irradiation increases p53-dependent Noxa mRNA and protein levels.
Ectopic expression of Noxa interacts with anti-apoptotic Bcl-2 family members, activating caspase-9 and inducing apoptosis via mitochondrial localization. Elevated levels of p53 and Noxa are associated with impaired tumor development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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