Thermo Fisher Scientific Huntingtin Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water.
• Centrifuge to remove any insoluble material.
• The peptide is homologous in rat and human.
• Specificity: Huntingtin.

Target Information

Huntingtin is a disease gene linked to Huntington’s disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons. This is caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, translating as a polyglutamine repeat in the protein product.

HD is a mid-life onset autosomal dominant neurodegenerative disease characterized by psychiatric disorders, dementia, and involuntary movements (chorea), leading to death in 10–20 years. The huntingtin locus spans approximately 180 kb with 67 exons.

The huntingtin gene is widely expressed and required for normal development. It is expressed as two alternatively polyadenylated forms with different abundance in fetal and adult tissues. The larger transcript (~13.7 kb) is predominant in brain, while the smaller (~10.3 kb) is more widely expressed.

The genetic defect leading to Huntington’s disease may not necessarily eliminate transcription but may alter mRNA or protein function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.