Thermo Fisher Scientific Phospho-MAP2K4 (Ser257) Recombinant Rabbit Monoclonal Antibody (SEK1MKK4S257-C5), APC
APC 형광으로 표지된 재조합 Rabbit Monoclonal 항체로, 인산화 MAP2K4(Ser257)를 검출합니다. Flow Cytometry에 최적화되어 있으며 Human, Mouse, Rat 등 다양한 종에 반응합니다. Protein A/G로 정제된 액상 형태로 4°C에서 보관합니다.
- 판매단위
- pk
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 5 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SEK1MKK4S257-C5 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Ser257 of human phospho SEK1/MKK4 |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.20% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897074 |
Additional Formats
Target Information
MAP2K4 (MEK4) serine/threonine kinase (mitogen-activated protein kinase 4) is a dual specificity kinase of the STE7 family that phosphorylates and activates JNK1 and JNK2 as well as p38.
MAP2K4 preferentially phosphorylates the tyrosine residue of JNKs and mediates various physiological and pathophysiological processes such as responses to cellular stresses and inflammatory cytokines.
MAP2K4 plays an important role in carcinogenesis; loss-of-function mutations have been found in lung and pancreatic tumors, while a pro-oncogenic role has also been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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