Thermo Fisher Scientific Phospho-CCR5 (Ser349) Recombinant Mouse Monoclonal Antibody (E11/19)
Phospho-CCR5 (Ser349) 인산화 단백질을 검출하는 재조합 마우스 단클론 항체로, Western blot, ICC/IF, ELISA, IP 등 다양한 분석에 적합. HEK293 세포에서 발현되며 Protein A로 정제됨. 인간 CCR5에 특이적이며 HIV 연구에 유용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| ELISA | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | E11/19 |
| Immunogen | Synthetic phosphopeptide (CEAPERA(pS)(pS)VYTR(pS)TGEQI(pS)VGL) corresponding to the C-terminal region of human CCR5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074734 |
Product Specific Information
The E11/19 monoclonal antibody binds to phosphoserine 349 corresponding to the C-terminal 22 amino acid residues of human CCR5. CCR5 acts as a receptor for inflammatory CC-chemokines such as CCL3 (MIP-1α), CCL4 (MIP-1β), and RANTES.
Target Information
Human immunodeficiency virus (HIV) and related viruses require coreceptors in addition to CD4 to infect target cells. CCR5, along with CXCR4, CCR3, CCR2b, and CCR8, are chemokine receptors identified as HIV coreceptors. CCR5 (CC-CKR-5) is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains, facilitating fusion and entry into human white blood cells. CCR5 is essential for infection by HIV-1, HIV-2, and SIV. Beta-chemokines RANTES, MIP-1α, and MIP-1β are natural ligands for CCR5 and can prevent M-tropic HIV-1 infection. CCR5 interacts with the CD4-gp120 complex of HIV, leading to membrane fusion and viral entry. CCR5 mRNA is expressed in lymphoid organs and monocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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