Thermo Fisher Scientific CCR5 Chimeric Recombinant Rabbit Monoclonal Antibody (T21/8)
CCR5 단백질을 인식하는 재조합 토끼 단일클론 항체로, WB, ICC/IF, Flow Cytometry 등 다양한 응용에 적합. 인간 CCR5 N-말단에 특이적으로 결합하며, HIV 연구 및 케모카인 수용체 분석에 활용 가능. 단백질 A 정제, 액상 형태, 4°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | Assay-dependent | - |
| Immunocytochemistry (ICC/IF) | 10 µg/mL | - |
| Flow Cytometry (Flow) | 1:100 | - |
| ELISA | Assay-dependent | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | T21/8 |
| Immunogen | This antibody was raised by immunizing mice with intact RBL-CCR5 cells. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074733 |
Product Specific Information
- Specificity: T21/8 antibody binds with high affinity to a CCR5 N-terminal epitope.
- CCR5 is a receptor for several inflammatory CC-chemokines, including CCL3 (MIP-1α), CCL4 (MIP-1β), and RANTES.
Target Information
Human immunodeficiency virus (HIV) and related viruses require coreceptors, in addition to CD4, to infect target cells.
CCR5, along with CXCR4, CCR3, CCR2b, and CCR8, acts as a coreceptor for macrophage- and dual-tropic HIV-1 strains.
CCR5 is essential for HIV-1, HIV-2, and SIV infection. Beta-chemokines such as RANTES, MIP-1α, and MIP-1β are natural ligands for CCR5 and can inhibit M-tropic HIV-1 infection.
CCR5 interacts with the CD4-gp120 complex of HIV, facilitating membrane fusion and viral entry into target cells.
CCR5 mRNA is expressed in lymphoid organs and monocytes.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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