Thermo Fisher Scientific CD104 (Integrin Beta-4) (Squamous Cell Carcinoma Antigen) Monoclonal Antibody (UM-A9)

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1–2 µg/mL
• Publications: –

Flow Cytometry (Flow)

• Tested Dilution: 1–2 µg/10⁶ cells
• Publications: –

Blocking Assay (BLOCK)

• Tested Dilution: Assay-dependent
• Publications: –

Product Specifications

Target Information

Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion and transduce signals that regulate gene expression and cell growth.
This gene encodes the integrin beta 4 subunit, a receptor for laminins. It tends to associate with the alpha 6 subunit and plays a pivotal role in invasive carcinoma biology. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.