Thermo Fisher Scientific CD49f (Integrin alpha 6) Monoclonal Antibody (eBioGoH3 (GoH3)), APC, eBioscience
CD49f(Integrin α6) 단백질을 인식하는 Rat IgG2a 단클론 항체로, 인간 및 마우스 시료에 반응합니다. APC 형광 표지로 유세포 분석(Flow Cytometry)에 적합하며, 세포 접착 및 신호전달 연구에 활용됩니다. 4°C 암소 보관, 동결 금지.
- 카탈로그번호
- 17-0495-8x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD49f (Integrin alpha 6) Monoclonal Antibody (eBioGoH3 (GoH3)), APC, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Flow Cytometry (Flow) | 0.125 µg/test | View 55 publications |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBioGoH3 (GoH3) |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2016626 |
Available Formats
- Unconjugated
- Alexa Fluor 700
- APC-eFluor 780
- Biotin
- eFluor 450
- FITC
- PE
- PE-Cyanine7
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Super Bright 780
- Request custom conjugation
Product Specific Information
Description:
The eBioGoH3 monoclonal antibody reacts with mouse and human CD49f (Integrin alpha 6), also known as very late activation antigen 6 (VLA-6 alpha chain) and platelet gpIc. CD49f is a 120 kDa transmembrane protein that associates with CD29 (integrin beta 1) to form the VLA-6 complex, and with CD104 (integrin beta 4) to form the α6β4 complex. It is expressed primarily on T cells, monocytes, platelets, epithelial, and endothelial cells, and has also been found on germinal center B cells.
The eBioGoH3 antibody cross-reacts with integrin alpha 6 on human, mouse, and bovine cells, and can block binding of integrin alpha 6 to laminin.
Applications Reported:
This antibody is reported for use in flow cytometric analysis.
Applications Tested:
Tested by flow cytometric analysis of normal human peripheral blood cells. Recommended ≤0.125 µg per test (100 µL final volume). Cell number may range from 10⁵–10⁸ cells/test. Optimize titration for best performance.
Fluorescence Characteristics:
- Excitation: 633–647 nm
- Emission: 660 nm
- Laser: Red Laser
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
CD49f (Integrin alpha-6, ITGA6)
Integrins are cell-surface proteins composed of alpha and beta chains that mediate cell adhesion and signaling. Alpha 6 may combine with beta 4 (forming TSP180) or beta 1 (forming VLA-6). These complexes regulate cell adhesion, cytoskeletal organization, and signaling linked to proliferation and survival.
CD49f is predominantly expressed in epithelial cells and plays a structural role in hemidesmosomes. Integrins connect the extracellular matrix (ECM) with intracellular cytoskeletal proteins and integrate ECM interactions with growth factor signaling. Over 18 alpha and 8 beta subunits exist in mammals, with multiple isoforms and splice variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.