Thermo Fisher Scientific alpha-2c Adrenergic Receptor Monoclonal Antibody (N330A/80), PerCP

Applications and Tested Dilution

Product Specifications

Additional Formats

• Unconjugated
• APC
• FITC
• PE
• Request custom conjugation

Product Specific Information

1 µg/mL of MA5-45617 was sufficient for detection of Alpha2C Adrenergic Receptor in 20 µg of COS cells transiently transfected with HA-tagged Alpha-lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. Detects 50 kDa or larger (possibly due to dimerization). Does not cross-react with other adrenergic receptors.
This antibody was formerly sold as clone S330A-80.

Target Information

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor (GPCR) superfamily, including three highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors regulate neurotransmitter release from sympathetic nerves and adrenergic neurons in the central nervous system.
Mouse studies revealed that both alpha2A and alpha2C subtypes are required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and central noradrenergic neurons. The alpha2A subtype inhibits transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulates neurotransmission at lower levels of nerve activity.
This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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