Thermo Fisher Scientific alpha-2c Adrenergic Receptor Monoclonal Antibody (N330A/80), FITC

Thermo Fisher Scientific alpha-2c Adrenergic Receptor Monoclonal Antibody (N330A/80), FITC

Applications and Tested Dilution

Species Reactivity

Human, Mouse

Host / Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

N330A/80

Immunogen

Synthetic peptide amino acids 442–462 (QDFRRSFKHILFRRRRRGFRQ, cytoplasmic C-terminus) of human Alpha-2C adrenergic receptor.

Conjugate

FITC

Additional Formats:

• Unconjugated (MA5-27724)
• APC (MA5-45615)
• PE (MA5-45618)
• PerCP (MA5-45617)
• Custom conjugation available upon request

Excitation / Emission Max

498 / 517 nm

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage Buffer

9.1 mM sodium bicarbonate/PBS (pH 7.4), with 640.91 mM DMSO and 136.36 mM ethanolamine

Contains

No preservative

Storage Conditions

4°C, store in dark

Shipping Conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2932070

Product Specific Information

1 µg/mL of MA5-45616 was sufficient for detection of Alpha2C Adrenergic Receptor in 20 µg of COS cells transiently transfected with HA-tagged Alpha-lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Detects 50 kDa or larger (possibly due to dimerization). Does not cross-react with other adrenergic receptors.
This antibody was formerly sold as clone S330A-80.

Target Information

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily, including three highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors regulate neurotransmitter release from sympathetic nerves and adrenergic neurons in the central nervous system.
Mouse studies show both alpha2A and alpha2C subtypes are required for normal presynaptic control of transmitter release. Alpha2A inhibits release at high stimulation frequencies, while alpha2C modulates neurotransmission at lower activity levels.
This gene encodes the alpha2C subtype, which contains no introns in its coding or untranslated sequences.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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