Thermo Fisher Scientific alpha-2c Adrenergic Receptor Monoclonal Antibody (N330A/80), FITC
FITC로 표지된 알파-2C 아드레날린 수용체 단클론 항체로, 인간 및 생쥐 시료에 반응합니다. Western blot 및 면역세포화학에 적합하며, 높은 특이성과 재현성을 제공합니다. 단백질 G로 정제된 액상 형태로, 형광 분석에 최적화되어 있습니다.
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Thermo Fisher Scientific alpha-2c Adrenergic Receptor Monoclonal Antibody (N330A/80), FITC
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
Species Reactivity
Human, Mouse
Host / Isotype
Mouse / IgG1
Class
Monoclonal
Type
Antibody
Clone
N330A/80
Immunogen
Synthetic peptide amino acids 442–462 (QDFRRSFKHILFRRRRRGFRQ, cytoplasmic C-terminus) of human Alpha-2C adrenergic receptor.
Conjugate
FITC
Additional Formats:
- Unconjugated (MA5-27724)
- APC (MA5-45615)
- PE (MA5-45618)
- PerCP (MA5-45617)
- Custom conjugation available upon request
Excitation / Emission Max
498 / 517 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage Buffer
9.1 mM sodium bicarbonate/PBS (pH 7.4), with 640.91 mM DMSO and 136.36 mM ethanolamine
Contains
No preservative
Storage Conditions
4°C, store in dark
Shipping Conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2932070
Product Specific Information
1 µg/mL of MA5-45616 was sufficient for detection of Alpha2C Adrenergic Receptor in 20 µg of COS cells transiently transfected with HA-tagged Alpha-lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Detects 50 kDa or larger (possibly due to dimerization). Does not cross-react with other adrenergic receptors.
This antibody was formerly sold as clone S330A-80.
Target Information
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily, including three highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors regulate neurotransmitter release from sympathetic nerves and adrenergic neurons in the central nervous system.
Mouse studies show both alpha2A and alpha2C subtypes are required for normal presynaptic control of transmitter release. Alpha2A inhibits release at high stimulation frequencies, while alpha2C modulates neurotransmission at lower activity levels.
This gene encodes the alpha2C subtype, which contains no introns in its coding or untranslated sequences.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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