Thermo Fisher Scientific CD19 Monoclonal Antibody (6OMP31), Biotin, eBioscience
CD19 단백질을 인식하는 6OMP31 클론의 Rat 모노클로날 항체로 Biotin 결합형입니다. 인간, 마우스, 랫트 시료에 반응하며 IHC(F/P) 및 Western blot에 사용 가능합니다. B세포 발달 및 활성 연구에 적합하며 4°C 암소 보관이 권장됩니다.
- 카탈로그번호
- 13-0194-8x (2개 옵션)
- 판매단위
- pk
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Thermo Fisher Scientific CD19 Monoclonal Antibody (6OMP31), Biotin, eBioscience™
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | - |
| Immunohistochemistry (IHC) | - | 7 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1 µg/mL | - |
| Immunohistochemistry (Frozen) (IHC (F)) | 1 µg/mL | 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), Biotin, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6OMP31 |
| Conjugate | Biotin |
| Available Formats | Unconjugated, Alexa Fluor 488, Custom conjugation |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2637168 |
| Filtration | 0.2 µm post-manufacturing filtered |
Product Specific Information
The 6OMP31 monoclonal antibody reacts with human, mouse, and rat CD19. CD19 is a transmembrane glycoprotein belonging to the immunoglobulin superfamily, expressed by B cells throughout development except on plasma cells and follicular dendritic cells. It acts as a B cell co-receptor, forming complexes with CD21, CD81, Leu13, and MHC class II, and plays a key role in B cell activation and proliferation.
CD19 deficiency leads to impaired humoral immunity, while mutations are linked to immunodeficiency syndromes. CD19 is expressed on most B cell tumors, including acute lymphoblastic leukemia and B cell lymphomas. CD19 antibodies are under investigation for therapeutic use in lymphoma, leukemia, and autoimmune disorders.
Applications Reported: Western blotting, immunohistochemistry on frozen and paraffin-embedded sections.
Applications Tested: Effective at ≤1 µg/mL for IHC (P) and IHC (F) with appropriate antigen retrieval. Optimal titration recommended.
Target Information
CD19, a member of the immunoglobulin superfamily, has two Ig-like domains and is expressed on all peripheral B cells. It may also appear on myeloid leukemia cells. CD19 acts as a signal-amplifying co-receptor for the B cell receptor (BCR), regulating B cell proliferation and differentiation. Mutations cause hypogammaglobulinemia, while overexpression leads to B cell hyperactivity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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