Thermo Fisher Scientific Phospho-BAP1 (Ser592) Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

This antibody detects endogenous levels of BAP1 only when phosphorylated at Ser592.

Target Information

BRCA1-associated protein-1 (BAP1) interacts with the RING finger domain of BRCA1. The N-terminal 240 amino acids of the 729-amino acid human protein show homology to ubiquitin C-terminal hydrolases (UCHs), which catalyze proteolytic processing of ubiquitin. BAP1 contains an acidic region, a highly charged C-terminal region, and two putative nuclear localization signals.
BAP1 and BRCA1 associate in vivo and have overlapping subnuclear localization patterns. BAP1 enhances BRCA1-mediated inhibition of breast cancer cell growth.
Northern blot analysis shows BAP1 expression as a 4-kb mRNA in all human tissues tested, and a 4.8-kb transcript expressed exclusively in testis. BAP1 and BRCA1 are coexpressed during murine breast development and remodeling.
The BAP1 gene is mapped to 3p21.3, a region of loss of heterozygosity for breast cancer and frequently deleted in lung carcinomas. Intragenic homozygous rearrangements and deletions of BAP1 appear in lung carcinoma cell lines. It has been postulated that BAP1 functions as a tumor suppressor gene in the BRCA1 growth control pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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