Thermo Fisher Scientific CD328 (Siglec7) Monoclonal Antibody (eBioQA79 (QA79)), eBioscience

Thermo Fisher Scientific CD328 (Siglec7) Monoclonal Antibody (eBioQA79 (QA79)), eBioscience

Applications and Tested Dilution

Publications: View 2 publications

Product Specifications

Additional Formats:

• PE Conjugate
• Request custom conjugation

Product Specific Information

The eBioQA79 monoclonal antibody reacts with adhesion inhibitory receptor molecule 1 (AIRM1), also known as sialic acid binding immunoglobulin-like lectin 7 (Siglec-7), p75, and CDw328.
AIRM1 is a cell surface receptor belonging to the sialoadhesin family and shows homology with CD33. Expression is confined to NK cells in lymphoid tissues, and crosslinking with eBioQA79 inhibits NK cell function.
p75/AIRM1 is expressed during various stages of myeloid differentiation and is useful for monitoring cellular proliferation, particularly in diseases such as chronic myeloid leukemia.

Applications Reported: Flow cytometric analysis and immunoprecipitation.
Applications Tested: Flow cytometric analysis at ≤ 0.5 µg/test. A test is defined as staining a cell sample in 100 µL volume. Cell numbers may vary from 10⁵ to 10⁸ per test and should be optimized empirically.

Target Information

Putative adhesion molecule mediating sialic-acid dependent binding to cells. Preferentially binds α-2,3- and α-2,6-linked sialic acid, as well as disialogangliosides.
The sialic acid recognition site may be masked by cis interactions on the same cell surface. In the immune response, acts as an inhibitory receptor via tyrosine phosphorylation and recruitment of phosphatases that block signal transduction.
Mediates inhibition of NK cell cytotoxicity and may play a role in hemopoiesis by inhibiting differentiation of CD34⁺ precursors towards myelomonocytic lineage and proliferation of leukemic myeloid cells (in vitro).

For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.