Thermo Fisher Scientific Phospho-LAT (Tyr255) Polyclonal Antibody
LAT 단백질의 Tyr255 인산화 상태를 특이적으로 인식하는 폴리클로날 항체. Western blot 및 면역세포염색에 적합. 인간, 마우스, 랫트 반응성. 고순도 정제 및 안정한 PBS/glycerol 저장용액 제공.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human LAT (Accession O43561), corresponding to amino acid residues around phosphorylated Tyr255. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817542 |
Product Specific Information
This antibody detects endogenous levels of LAT only when phosphorylated at Tyr255.
Target Information
LAT (Linker for Activation of T cells) is a 36–38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells, and platelets. Upon immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell activation and FcepsilonRI-dependent mast cell activation, as well as for early thymocyte maturation. It also plays roles in NK cell signaling and platelet activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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