Thermo Fisher Scientific Clostridium tetani Tetanus Toxin Polyclonal Antibody
Clostridium tetani 유래 파상풍 독소를 인식하는 염소 폴리클로날 항체. WB 및 ELISA에 적합하며, 고순도 Affinity chromatography 정제 제품. 연구용으로만 사용 가능하며 4°C 단기, -20°C 장기 보관 권장.
- 카탈로그번호
- PA533146
- 판매단위
- pk
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Thermo Fisher Scientific Clostridium tetani Tetanus Toxin Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1:100–1:500
- ELISA: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bacteria |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Tetanus Exotoxin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550593 |
Product Specific Information
Goat anti-tetanus exotoxin antibody recognizes tetanus toxin, also known as tentoxylysin, produced by the soil microorganism Clostridium tetani.
Target Information
Tetanus toxin is a neurotoxin produced by Clostridium tetani. It causes tetanus, characterized by prolonged contraction of skeletal muscles. Approximately 1 million cases occur annually worldwide, resulting in 300,000–500,000 deaths, mainly in developing countries.
The toxin (~150 kDa) consists of a heavy chain (100 kDa) and a light chain (50 kDa) connected by a disulfide bond. It inhibits neurotransmitter release by binding to peripheral neuronal synapses, internalizing, and moving retrogradely along axons into the spinal cord. It blocks GABA and glycine release via synaptobrevin-2 inhibition, leading to muscle overactivity. The binding to neurons is irreversible.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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