Thermo Fisher Scientific NOTCH3 Polyclonal Antibody
NOTCH3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, ICC/IF, ELISA에 적합. 인간 NOTCH3의 751-850번 아미노산 서열을 기반으로 제작되었으며, 고순도 Affinity Chromatography 정제. 연구용으로만 사용 가능.
- 카탈로그번호
- PA5120058
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | - |
| ELISA | 1 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 751–850 of human NOTCH3 (NP_000426.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.58 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2913630 |
Product Specific Information
- Positive test controls include: Rat skeletal muscle
- Localization: Cell membrane, Nucleus, Single-pass type I membrane protein
Immunogen sequence:
SDGMGFHCTC PPGVQGRQCE LLSPCTPNPC EHGGRCESAP GQLPVCSCPQ GWQGPRCQQD VDECAGPAPC GPHGICTNLA GSFSCTCHGG YTGPSCDQDI
Target Information
NOTCH3 is the third discovered human homologue of the Drosophila melanogaster type I membrane protein notch. In Drosophila, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway crucial for neural development.
Human homologues of these ligands have also been identified. NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1 to regulate cell-fate determination.
Mutations in NOTCH3 are linked to cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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