Thermo Fisher Scientific CD61 (Integrin beta 3) Monoclonal Antibody (VI-PL2), PE, eBioscience
CD61(Integrin β3)에 특이적인 VI-PL2 단클론 항체로, PE 형광표지되어 흐름세포분석(Flow Cytometry)에 최적화됨. 인간, 개, 비인간 영장류에 반응하며, 혈소판 응집 및 세포 접착 관련 연구에 유용. 4°C 암소 보관, 동결 금지.
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Thermo Fisher Scientific CD61 (Integrin beta 3) Monoclonal Antibody (VI-PL2), PE, eBioscience™
Applications and Tested Dilution
- Application: Flow Cytometry (Flow)
- Tested Dilution: 5 µL (0.06 µg)/test
- View 6 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Baboon, Dog, Cynomolgus monkey, Human, Rhesus monkey |
| Published Species | Dog, Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | VI-PL2 |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11042464 |
Available Formats
- Unconjugated
- APC
- APC-eFluor 780
- FITC
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 645
- Request custom conjugation
Product Specific Information
The VI-PL2 monoclonal antibody reacts with human CD61, also known as integrin beta 3 (GPIIIa).
CD61 is a 90–110 kDa member of the beta integrin family expressed by leukocytes, platelets, endothelial, and smooth muscle cells. It forms non-covalent complexes with alpha integrins CD41 and CD51, resulting in αIIbβ3 (CD41/CD61) and αvβ3 (CD51/CD61) heterodimers. These complexes mediate cellular adhesion, trafficking, proliferation, and differentiation.
- CD41/CD61 integrin: involved in platelet aggregation; binds fibrinogen, von Willebrand Factor (vWF), and fibronectin.
- CD51/CD61 integrin: binds vitronectin, fibronectin, vWF, and fibrinogen; regulates migration and survival of angiogenic endothelial cells.
This antibody cross-reacts with canine, baboon, rhesus, and cynomolgus monkey species.
Applications Reported: Flow cytometric analysis
Applications Tested: Pre-titrated and validated for flow cytometry at 5 µL (0.06 µg) per test.
A test = amount of antibody staining cells in 100 µL final volume (typically 10⁵–10⁸ cells/test).
Excitation: 488–561 nm; Emission: 578 nm; Laser: Blue, Green, Yellow-Green
Filtration: 0.2 µm post-manufacturing filtered
Target Information
CD61 (GPIIIa, ITGB3) is a glycoprotein expressed on megakaryocytes, platelets, and precursors. It acts as a receptor for fibrinogen, fibronectin, von Willebrand factor, and vitronectin, playing a key role in platelet aggregation and cell adhesion.
- Molecular Weight: ~105 kDa
- Associations: Forms complexes with αIIb (CD41) or αV (CD51) integrins
- Expression: Platelets, megakaryocytes, endothelial cells, monocytes, osteoclasts
- Functions: Cell adhesion and signaling
- Associated Diseases: Glanzmann Thrombasthenia, Platelet type-16 Bleeding Disorder
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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