Thermo Fisher Scientific CD61 (Integrin beta 3) Monoclonal Antibody (2C9.G3), PE, eBioscience
CD61 (Integrin beta 3) 단클론 항체로, 마우스 및 랫트 시료에서 사용 가능. PE 형광 표지로 유세포분석(Flow Cytometry)에 최적화. 혈소판 및 세포 부착 관련 연구에 적합하며, 높은 특이성과 안정성을 제공.
- 카탈로그번호
- 12-0611-8x (3개 옵션)
- 판매단위
- pk
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3개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD61 (Integrin beta 3) Monoclonal Antibody (2C9.G3), PE, eBioscience
Thermo Fisher Scientific CD61 (Integrin beta 3) Monoclonal Antibody (2C9.G3), PE, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | View 1 publication |
| Flow Cytometry (Flow) | 0.5 µg/test | View 17 publications |
Product Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Armenian hamster / IgG |
| Recommended Isotype Control | Armenian Hamster IgG Isotype Control (eBio299Arm), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2C9.G3 |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_465717 |
Available Formats
- Unconjugated
- APC
- Biotin
- FITC
- Functional Grade
- NovaFluor Blue 610-70S
- NovaFluor Blue 660-120S
- NovaFluor Red 725
- NovaFluor Yellow 570
- NovaFluor Yellow 660
- NovaFluor Yellow 730
- NovaFluor Yellow 755
- Request custom conjugation
Product Specific Information
The 2C9.G3 (HMb3-1) monoclonal antibody reacts with mouse and rat CD61, also known as integrin beta3. CD61 is expressed by activated T cells, granulocytes, and platelets. It associates non-covalently with integrin alphaV (CD51) to form the vitronectin receptor and with alphaIIb (CD41) to form gpIIb/IIIa. These complexes mediate adhesion to extracellular matrix components including fibrinogen, fibronectin, vitronectin, thrombospondin, and von Willebrand factor.
Applications Reported: Flow cytometric analysis
Applications Tested: Tested on mouse splenocytes and bone marrow cells at ≤0.5 µg/test (100 µL final volume). Optimal titration recommended.
Excitation: 488–561 nm
Emission: 578 nm
Laser Compatibility: Blue, Green, Yellow-Green
Filtration: 0.2 µm post-manufacturing filtered
Target Information
CD61 (GPIIIa, ITGB3) is a glycoprotein found on megakaryocytes, platelets, and their precursors. It functions as a receptor for fibrinogen, fibronectin, von Willebrand factor, and vitronectin, playing a key role in platelet aggregation and cell adhesion. CD61 forms heterodimers with either CD41 (alphaIIb) or CD51 (alphaV). It is expressed on platelets, megakaryocytes, endothelial cells, monocytes, and osteoclasts. Dysfunction of CD61 is associated with Glanzmann Thrombasthenia and Platelet type-16 Bleeding Disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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