Thermo Fisher Scientific ACE2 Polyclonal Antibody
인간 ACE2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot, IHC, ICC 등 다양한 응용에 적합. 항원 친화 크로마토그래피로 정제된 고품질 항체로, 인체 생리 및 SARS-CoV 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2 µg/mL | - |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 10 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 10 µg/mL | - |
| Inhibition Assays (IA) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to amino acids near the N-terminus of human ACE2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154258 |
Product Specific Information
- In Western blot applications, this antibody detects a band at ~90 kDa.
- Suggested positive control: human kidney tissue lysate.
- PA5-20045 can be used with blocking peptide PEP-0164.
Target Information
Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. ACE2 has also been shown to be a functional receptor for the SARS coronavirus.
ACE2 converts the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. Lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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