Thermo Fisher Scientific TRIM5 delta Polyclonal Antibody
TRIM5 delta 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC에 사용 가능. 인간 및 마우스 반응성. 항원 친화 크로마토그래피로 정제된 액상 제품. 1 mg/mL 농도, PBS 버퍼 및 sodium azide 함유. 연구용으로만 사용.
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Thermo Fisher Scientific TRIM5 delta Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2 µg/mL |
| Immunohistochemistry (IHC) | 1 µg/mL |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to 13 amino acids near the carboxy terminus of human TRIM5 delta |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11156425 |
Product Specific Information
- Detects a band at approximately 25 kDa in Western blot applications.
- Suggested positive control: mouse brain tissue lysate.
- Can be used with blocking peptide PEP-0167.
Target Information
TRIM5 belongs to a large family of proteins characterized by a tripartite motif comprising a RING domain, B-box type 1, B-box type 2, and a coiled-coil region.
TRIM5 has five alternatively spliced isoforms; the longest, TRIM5α, includes a C-terminal B30.2 (SPRY) domain.
Expression of TRIM5α variants from humans and other primates confers resistance to various retroviruses, including HIV-1, with differing efficiencies.
The TRIM5δ isoform colocalizes with BTBD1 and BTBD2 proteins in cytoplasmic bodies, acting as a scaffold for assembly of endogenous BTBD proteins.
TRIM5δ also exhibits autoubiquitination activity dependent on the RING finger and UbcH5B.
Usage
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-20048_TRIM5_delta_Q9C035-1_Rabbit.svg, PA5-20048_TRIM5_delta_Q9C035-1_Rabbit_PDP.jpeg)
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