Thermo Fisher Scientific c-Met Recombinant Rabbit Monoclonal Antibody (243), PE

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

5 µL/test

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

243

Immunogen

Recombinant protein ecoding Human c-Met (Met1-Thr932). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:c-Met,uniProtId:P08581-1,ncbiNodeId:9606,antigenRange:1-932,antigenLength:1390,antigenImageFileName:MA5-46682_c-Met_P08581-1_Rabbit.svg,antigenImageFileNamePDP:MA5-46682_c-Met_P08581-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

PE PE PE

View additional formats

• Unconjugated
• APC
• FITC
• Request custom conjugation

Excitation/Emission Max

565/576 nm View spectra

Form

Liquid

Concentration

100 µg/mL

Purification

Protein A

Storage buffer

PBS with 0.5% BSA

Contains

0.03% Proclin 300

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2937754

Product Specific Information

Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Human c-Met (Met1-Thr932) and conjugated with PE under optimum conditions, the unreacted PE was removed.

Storage: This antibody can be stored at 2C-8C for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze!

Target Information

MET (cMET) is a receptor-like tyrosine kinase whose dysregulation has been linked to many types of human malignancies. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation. It also plays a role in adults including wound healing, organ regeneration, and tissue remodeling. MET has been linked to cancers including gastric, renal, and breast; therefore, making it a target for cancer therapeutics and diagnostic testing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.