Thermo Fisher Scientific Phospho-Estrogen Receptor alpha (Ser106) Polyclonal Antibody
인간, 마우스, 랫트에서 인산화된 Estrogen Receptor alpha (Ser106)을 검출하는 폴리클로날 항체. Western blot, IHC, ICC/IF에 적합. 고순도 액상 형태로 PBS/glycerol 버퍼에 보존. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ESR1 (Accession P03372), corresponding to amino acid residues around phosphorylated Ser106 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818279 |
Product Specific Information
This antibody detects endogenous levels of Estrogen Receptor alpha only when phosphorylated at Serine 106.
Target Information
Estrogen Receptors (ER) belong to the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor acts as a ligand-activated transcription factor; upon estrogen binding, it undergoes a conformational change enabling dimerization and binding to estrogen response elements (ERE) in DNA. This binding regulates gene transcription through coactivator or corepressor recruitment.
There are two forms of the estrogen receptor, alpha (ESR1) and beta (ESR2), encoded by separate genes. Alternative RNA splicing generates at least four isoforms of ER-alpha (Isoform 1: 66 kDa, Isoform 2: 53 kDa, Isoform 3: 47 kDa, Isoform 4: 35 kDa). ERs are widely expressed in various tissues, essential for sexual development and reproduction, and also function in bone and other tissues. They are implicated in pathological processes including breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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