Thermo Fisher Scientific UPF2 Polyclonal Antibody
Thermo Fisher Scientific UPF2 Polyclonal Antibody는 인간 및 랫트 시료에 반응하는 고순도 항체로, Western blot과 IHC(Paraffin) 분석에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, mRNA 감시 및 NMD 연구에 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1153–1272 of human UPF2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720855 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum using epitope-specific immunogen. The purity is >95% (by SDS-PAGE).
Target Information
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance.
mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD).
When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons.
This protein is located in the perinuclear area and interacts with translation release factors and proteins homologous to yeast Upf1p and Upf3p.
Two splice variants have been found for this gene; both variants encode the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: PA5-77128_UPF2_Q9HAU5-1_Rabbit.svg)
(이미지: PA5-77128_UPF2_Q9HAU5-1_Rabbit_PDP.jpeg)
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