Thermo Fisher Scientific CYR61 Polyclonal Antibody
Thermo Fisher Scientific CYR61 Polyclonal Antibody는 인간 CYR61 단백질을 인식하는 비결합형 토끼 IgG 항체로, WB 및 ICC/IF에 적합합니다. 높은 특이성과 재현성을 제공하며, 인간 시료에만 반응합니다. 연구용으로 혈관형성 및 종양 진행 관련 연구에 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 | - |
| Neutralization (Neu) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide made to the human CYR61 protein sequence (between residues 250–350) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Wet ice |
| RRID | AB_2088728 |
Product Specific Information
This antibody does not react with mouse and rat samples despite 94% sequence homology.
Suggested positive control: antigen standard for CYR61 (transient overexpression lysate), MDA-MB-231 breast cancer cell lysate.
Target Information
CYR61 is a secreted heparin-binding protein encoded by a growth factor–inducible immediate-early gene that associates with the extracellular matrix and connective tissue. It belongs to the CCN family of angiogenic and vasculogenic regulators, including CTGF and Fisp12.
As an angiogenic inducer, CYR61 binds to integrin αvβ3, stimulating cell adhesion, migration, and DNA synthesis of human vascular endothelial cells. Expression increases during vessel growth, wound healing, and chondrocyte differentiation. It is detected in various tumors, promoting growth and serving as a marker of tumor progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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