Thermo Fisher Scientific FANCD2 Polyclonal Antibody
FANCD2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, 다양한 종에서 반응하며 WB, IHC, ICC, Flow 등 다중 응용 가능. 고순도 Affinity Chromatography 정제, 1 mg/mL 농도, 연구용 DNA 손상 복구 관련 연구에 적합.
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Thermo Fisher Scientific FANCD2 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2.5–5 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 5 µg/mL | - |
| Flow Cytometry (Flow) | 2–5 µg/mL | - |
| Immunoprecipitation (IP) | 1:10–1:500 | - |
| ChIP assay (ChIP) | Assay-Dependent | - |
| Inhibition Assays (IA) | Assay-Dependent | - |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Avian, Dog, Human, Marsupial, Mouse, Non-human primate, Rat, Zebrafish |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Human FANCD2 fusion protein (N-terminal fragment) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2102037 |
Product Specific Information
- In Western blot, this antibody recognizes a band at ~166 kDa (post-translationally modified form).
- Additional bands may appear at lower molecular weights.
- In immunofluorescence, tested in human MMC and IR-treated MEF cells.
- Suggested positive control: HeLa whole cell extract.
Target Information
FANCD2 (Fanconi anemia group D2 protein) is essential for maintaining chromosomal stability and ensuring accurate homolog pairing during meiosis. It participates in DNA double-strand break repair via homologous recombination and single-stranded annealing. FANCD2 stabilizes BLM under replicative stress and facilitates BRCA2/FANCD1 loading onto damaged chromatin.
Defects in the FANCD2 gene cause Fanconi anemia complementation group D2, resulting in anemia, leukopenia, and thrombopenia due to bone marrow dysfunction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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