Thermo Fisher Scientific Tankyrase Polyclonal Antibody
Tankyrase 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot과 Immunocytochemistry에 적합하며, Wnt 신호전달 및 텔로미어 조절 연구에 유용. 고농도(4.3 mg/mL) 액상 형태로 제공되며, 안정적인 단기(4°C)/장기(-20°C) 보관 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:250–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide made to a region of human Tankyrase within residues 250–350 (sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 4.3 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2205842 |
Product Specific Information
In Western blot, this antibody recognizes an endogenous band at ~150 kDa in whole cell extract and a band at ~180 kDa in baculovirus-derived his-tagged protein.
Suggested positive control: HeLa whole cell extract.
Target Information
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking.
Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, key components of the beta-catenin destruction complex.
Poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation.
Also mediates PARsylation of BLZF1, CASC3, TERF1, HEPACAM2/MIKI, and NUMA1, contributing to telomere regulation, centrosome maturation, and spindle pole assembly.
May regulate vesicle trafficking and modulate the subcellular distribution of GLUT4 vesicles.
Stimulates 26S proteasome activity.
[UniProt]
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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