Thermo Fisher Scientific PTPRN Polyclonal Antibody
PTPRN 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot, IHC, ICC/IF에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며 항원 친화 크로마토그래피로 정제되었습니다. 신경내분비 세포의 IA-2 단백질 연구에 유용합니다.
- 카탈로그번호
- PA576932
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (IHC) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full-length Human PTPRN (aa 1–979, UniProt ID: Q16849-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS (pH 7.2) with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720659 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum using an epitope-specific immunogen. The purity is >95% as determined by SDS-PAGE.
Target Information
IA-2 (insulinoma-associated protein 2, ICA512, PTPRN) is a member of the transmembrane protein tyrosine phosphatase (PTP) family located in secretory granules of neuroendocrine cells. The IA-2 protein is 979 amino acids long and consists of a luminal, transmembrane, and cytoplasmic domain. Although part of the PTP family, IA-2 lacks phosphatase activity due to amino acid substitutions at critical catalytic sites. IA-2 and its paralog IA-2β are major autoantigens in type 1 diabetes mellitus. Upon granule exocytosis, the IA-2 cytoplasmic fragment translocates to the nucleus, enhancing phosphorylated STAT5 and STAT3 levels, which promotes insulin gene transcription and granule biogenesis. IA-2 signaling supports pancreatic β-cell proliferation through STAT-regulated cyclin D expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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