Thermo Fisher Scientific PPOX Polyclonal Antibody
Thermo Fisher Scientific의 PPOX Polyclonal Antibody는 인간 및 마우스 시료에 반응하는 토끼 유래 다클론 항체입니다. Western blot 및 IHC(P) 실험에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 장기 보관 시 -20°C에서 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full-length Human PPOX (1–477 amino acids, UniProt ID: P50336-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720655 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. Purity is greater than 95% as determined by SDS-PAGE.
Target Information
Protoporphyrinogen oxidase (PPOX) is the penultimate enzyme in the heme biosynthetic pathway, catalyzing the 6-electron oxidation of protoporphyrinogen IX to protoporphyrin IX. PPOX localizes to the inner mitochondrial membrane in multiple tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Deficiency of PPOX causes variegate porphyria, an autosomal dominant disorder characterized by cutaneous photosensitivity and neurological symptoms. Homozygous variants result in severe PPOX deficiency, early-onset photosensitization, skeletal abnormalities, and, in some cases, short stature and neurological impairment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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