Thermo Fisher Scientific KRAS Monoclonal Antibody (OTI4F6), TrueMAB
KRAS 단백질을 표적으로 하는 Mouse IgG1 단클론 항체로, Western blot에 적합합니다. 인간 KRAS 전체 길이 재조합 단백질을 면역원으로 사용하였으며, 고순도 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
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Applications
- Western Blot (WB)
Tested Dilution
- 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4F6 |
| Immunogen | Full length human recombinant protein of human KRAS produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
K-RAS (GTPase KRas) belongs to the Ras oncogene family. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
It plays an important role in regulating cell proliferation and contributes to oncogenic processes by inducing transcriptional silencing of tumor suppressor genes in colorectal cancer cells in a ZNF304-dependent manner.
Mutations in KRAS are associated with acute myelogenous leukemia, juvenile myelomonocytic leukemia, Noonan syndrome, gastric cancer, and cardiofaciocutaneous syndrome 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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