Thermo Fisher Scientific ALK Monoclonal Antibody (OTI1E8), TrueMAB

Applications

• Western Blot (WB): 1:2,000 dilution tested

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, it is recommended to perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and plays a crucial role in brain development.
Mutations, rearrangements, and amplifications in the ALK gene are associated with tumors such as anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer.
Chromosomal translocation often results in the NPM-ALK fusion gene, producing an oncogenic protein.
ALK is a receptor tyrosine kinase with transmembrane and extracellular domains, showing high sequence similarity to LTK, and is important for neuronal signaling.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.