Thermo Fisher Scientific CARD14 Polyclonal Antibody
Human CARD14 단백질을 인식하는 토끼 폴리클로날 항체로, IHC 등 연구용으로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS 버퍼에 0.02% sodium azide 포함. 냉장 또는 냉동 보관 가능.
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: 5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | 14 amino acid synthetic peptide near the carboxy terminus of human CARMA2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551715 |
Product Specific Information
PA5-34363 can be used with blocking peptide PEP-1406.
Target Information
Membrane-associated guanylate kinase (MAGUK) family members localize to the plasma membrane and function as molecular scaffolds for assembling multi-protein complexes.
The MAGUK family includes several mammalian proteins related to the Drosophila tumor suppressor discs-large (dlg) gene product, such as postsynaptic proteins, GKAPs, tight junction associated proteins (ZO-1–3), and caspase-associated recruitment domain (CARD) proteins: CARD 6, CARD 8–12, and CARD 14.
CARD 14 is a 1,004 amino acid protein consisting of:
- N-terminal CARD domain
- Central coiled-coil domain
- C-terminal tripartite domain (PDZ, Src homology 3, and GUK domains)
CARD 14 is expressed in the placenta where it positively regulates apoptosis and controls NF-kappaB activation by phosphorylating BCL10, a signaling protein that activates NF-kappaB through the I kappaB kinase complex.
Epigallocatechin-3-gallate (EGCG) is a polyphenol that induces the expression of CARD 14.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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