Thermo Fisher Scientific CARD14 Polyclonal Antibody

Applications

Immunohistochemistry (IHC)

• Tested Dilution: 5 µg/mL

Product Specifications

Product Specific Information

PA5-34363 can be used with blocking peptide PEP-1406.

Target Information

Membrane-associated guanylate kinase (MAGUK) family members localize to the plasma membrane and function as molecular scaffolds for assembling multi-protein complexes.
The MAGUK family includes several mammalian proteins related to the Drosophila tumor suppressor discs-large (dlg) gene product, such as postsynaptic proteins, GKAPs, tight junction associated proteins (ZO-1–3), and caspase-associated recruitment domain (CARD) proteins: CARD 6, CARD 8–12, and CARD 14.

CARD 14 is a 1,004 amino acid protein consisting of:

• N-terminal CARD domain
• Central coiled-coil domain
• C-terminal tripartite domain (PDZ, Src homology 3, and GUK domains)

CARD 14 is expressed in the placenta where it positively regulates apoptosis and controls NF-kappaB activation by phosphorylating BCL10, a signaling protein that activates NF-kappaB through the I kappaB kinase complex.
Epigallocatechin-3-gallate (EGCG) is a polyphenol that induces the expression of CARD 14.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.