Thermo Fisher Scientific GLRA1 Monoclonal Antibody (3F1)
GLRA1 단백질을 인식하는 Mouse IgG2a 단클론 항체로, Western blot 및 ELISA에 적합합니다. 인간 유래 GLRA1에 반응하며, PBS(pH 7.4) 용액 상태로 제공됩니다. 보존제 무첨가, -20°C 보관, 연구용 전용 제품입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 0.03 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3F1 |
| Immunogen | GLRA1 (NP_000162, 121 a.a.–approximately 220 a.a.) partial recombinant protein with GST tag. MW of GST tag alone is 26 kDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
IWKPDLFFAN EKGAHFHEIT TDNKLLRISR NGNVLYSIRI TLTLACPMDL KNFPMDVQTC IMQLESFGYT MNDLIFEWQE QGAVQVADGL TLPQFILKEE
Target Information
GLRA1 is a subunit of a pentameric inhibitory glycine receptor, mediating postsynaptic inhibition in the central nervous system.
Defects in GLRA1 are associated with startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome.
Multiple transcript variants encoding different isoforms have been identified.
Glycine receptors (GlyR) containing GLRA1 belong to the cys-loop family of ligand-gated ion channels, responsible for the inhibitory effects of glycine.
GLRA1 is widely distributed in the CNS, particularly in the hippocampus, spinal cord, and brain stem.
Diseases associated with GLRA1 include Hyperekplexia, Hereditary 1, and Hyperekplexia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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