Thermo Fisher Scientific GLI3 Monoclonal Antibody (2C9)
GLI3 단백질을 표적으로 하는 Mouse IgG2a 단일클론 항체로, Western blot, ICC/IF, ELISA, PLA 등에 사용 가능. 고순도 친화 크로마토그래피 정제, PBS 버퍼에 보존, 인체 GLI3 반응성. 연구용으로만 사용.
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Thermo Fisher Scientific GLI3 Monoclonal Antibody (2C9)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 1 ng/mL |
| in situ PLA | 1:1200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2C9 |
| Immunogen | GLI3 (NP_000159, 1–110 a.a.) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MEAQSHSSTT TEKKKVENSI VKCSTRTDVS EKAVASSTTS NEDESPGQTY HRERRNAITM QPQNVQGLSK VSEEPSTSSD ERASLIKKEI HGSLPHVAEP SVPYRGTVFA
Target Information
This gene encodes a protein belonging to the C2H2-type zinc finger proteins subclass of the Gli family. These proteins function as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The encoded protein localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It also plays a role in embryogenesis. Mutations in this gene are associated with several diseases, including:
- Greig cephalopolysyndactyly syndrome
- Pallister-Hall syndrome
- Preaxial polydactyly type IV
- Postaxial polydactyly types A1 and B
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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