Thermo Fisher Scientific Phospho-MEK1 (Thr286) Polyclonal Antibody
Phospho-MEK1 (Thr286) 항체로, 인산화된 MEK1 단백질 검출에 특이적입니다. Western blot, IHC, ICC/IF에 사용 가능하며, Human, Mouse, Rat 시료에 반응합니다. Rabbit polyclonal 항체로, PBS/glycerol 용액 형태로 제공됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MAP2K1 (Accession Q02750), corresponding to amino acid residues around phosphorylated Thr286 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816088 |
Product Specific Information
This antibody detects endogenous levels of MEK1 only when phosphorylated at Thr286.
Target Information
MAP2K1 (MEK1) kinase is a dual-specificity protein kinase functioning in the MAPK signaling cascade, regulating cell growth and differentiation. It is activated by various growth factors, cytokines, and calcium influx. MEK1 activation occurs via phosphorylation at Ser218 and Ser222 by Raf1. It plays roles in stress response, apoptosis, and proliferation signaling. Mutations in MAP2K1 are associated with cardiofaciocutaneous syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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