Thermo Fisher Scientific Phospho-L-Plastin (Tyr28) Polyclonal Antibody
Phospho-L-Plastin (Tyr28)을 인식하는 토끼 폴리클로날 항체로, 인산화된 L-Plastin의 내인성 수준을 검출합니다. Western blot 및 IHC(P)에서 사용 가능하며, 연구용으로만 제공됩니다. -20°C에서 보관하며 액상 형태로 제공됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human LCP1 (Accession P13796), corresponding to amino acid residues around phosphorylated Tyr28 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816084 |
Product Specific Information
This antibody detects endogenous levels of Plastin L only when phosphorylated at Tyr28.
Target Information
L-plastin is a leukocyte-specific actin-bundling protein from the fimbrin family. It contains two actin-binding domains and two EF-hand type calcium-binding domains. Phosphorylation occurs on a serine residue in its headpiece region in response to inflammatory stimuli. L-plastin may regulate integrin-mediated adhesion in leukocytes and is expressed in most human cancer cell lines derived from solid tumors. Its expression is upregulated by testosterone in androgen receptor–positive prostate and breast cancer cells through three androgen receptor binding elements located upstream of the gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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