Thermo Fisher Scientific Phospho-DP2 Prostanoid Receptor (Ser338, Ser339) Polyclonal Antibody
Phospho-DP2 (Ser338, Ser339) 폴리클로날 항체로, 인간 CRTH2 단백질의 인산화 부위를 인식합니다. Western blot에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 4°C 또는 -20°C에서 보관 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human DP2 around the phosphorylation site of Ser338/Ser339 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Dulbecco’s PBS, pH 7.4 |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice (domestic); Dry ice (international) |
Target Information
CRTH2 (GPR44) is a chemoattractant receptor-homologous molecule expressed on Th2 cells that acts as a receptor for prostaglandin D2 (PGD2). It mediates chemotaxis of Th2 cells and eosinophils toward PGD2, playing a key role in allergic responses. Interestingly, CRTH2-deficient mice show enhanced eosinophil recruitment and elevated IL-5 and IL-3 production, suggesting CRTH2 restricts eosinophilia and allergic inflammation.
CRTH2 is a member of the G protein-coupled leukocyte chemoattractant receptor family, selectively expressed in Th2 but not Th1 cells. It is found in the central nervous system and peripheral tissues, particularly in activated Th2 cells. Two transcripts (3.5 kb and 3.4 kb) have been identified, showing tissue-specific expression patterns. Single nucleotide polymorphisms in its 3' UTR are associated with asthma susceptibility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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