Thermo Fisher Scientific Phospho-Tau (Thr231) Monoclonal Antibody (AT180)
Phospho-Tau (Thr231) 단백질을 특이적으로 인식하는 AT180 모노클론 항체로, PHF-Tau 및 신경섬유 엉킴 검출에 적합합니다. Western blot, IHC, ELISA 등 다양한 응용 가능하며, 인산화된 Thr231 잔기에 특이적입니다. 인간 및 랫트 반응성.
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Thermo Fisher Scientific Phospho-Tau (Thr231) Monoclonal Antibody (AT180)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–5 µg/mL | 132 |
| Immunohistochemistry (IHC) | – | 119 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–5 µg/mL | 12 |
| Immunohistochemistry (Frozen) (IHC (F)) | – | 1 |
| Immunohistochemistry - Free Floating (IHC (Free)) | – | 4 |
| Immunocytochemistry (ICC/IF) | – | 15 |
| Flow Cytometry (Flow) | – | 1 |
| ELISA | 2–10 µg/mL | 1 |
| Miscellaneous PubMed (Misc) | – | 10 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | C. elegans, Cat, Chicken, Dog, Fruit fly, Hamster, Horse, Human, Mouse, Non-human primate, Rabbit, Rat, Yeast |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AT180 |
| Immunogen | Partially purified human PHF-Tau |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Purified |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_223649 |
Product Specific Information
MN1040 recognizes PHF-Tau and tangles, and cross-reacts weakly with normal Tau. It does not cross-react with recombinant unphosphorylated human Tau.
The epitope of this antibody is the phosphorylated Thr231 residue (numbering according to human Tau40).
MN1040 detects PHF-Tau (Thr231) with a predicted molecular weight of approximately 79 kDa.
Purity is >95% as determined by SDS-PAGE.
Target Information
Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules.
The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, functioning as a linker between both.
Hyper-phosphorylated Tau forms paired helical filaments (PHF), the building blocks of neurofibrillary lesions in Alzheimer’s disease (AD) brain.
This phosphorylation impairs microtubule binding, leading to destabilization and neuronal degeneration.
Tau phosphorylation is mediated by kinases such as GSK-3β, PKA, cdk5, and casein kinase II.
Hyper-phosphorylated Tau is found in AD and other CNS disorders, including Pick’s disease, frontotemporal dementia, cortico-basal degeneration, and progressive supranuclear palsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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