Thermo Fisher Scientific Tau Monoclonal Antibody (HT7)
상품 옵션 정보 | ||||||||
---|---|---|---|---|---|---|---|---|
카탈로그 번호 | CAS 번호 | 설명 | 상태 | 단위 | 판매가 | 할인가 | 가격(VAT포함) | 수량 / 장바구니 / 찜 |
MN1000 | - | Thermo Fisher Scientific MN1000 Tau Monoclonal Antibody (HT7) 100 ug pk | 재고문의 | pk | 600,000원 | - | 660,000원 |
다른 상품 둘러보기
Applications
Tested Dilution
Publications
Western Blot (WB)
1-5 µg/mL
View 112 publications 112 publications
Immunohistochemistry (IHC)
-
View 48 publications 48 publications
Immunohistochemistry (Paraffin) (IHC (P))
5-10 µg/mL
View 6 publications 6 publications
Immunohistochemistry (PFA fixed) (IHC (PFA))
-
View 3 publications 3 publications
Immunohistochemistry (Frozen) (IHC (F))
-
View 3 publications 3 publications
Immunohistochemistry - Free Floating (IHC (Free))
Assay-dependent
View 2 publications 2 publications
Immunocytochemistry (ICC/IF)
-
View 22 publications 22 publications
ELISA (ELISA)
2-10 µg/mL
View 10 publications 10 publications
Immunoprecipitation (IP)
-
View 9 publications 9 publications
Neutralization (Neu)
-
View 1 publication 1 publication
Functional Assay (Functional)
-
View 2 publications 2 publications
Dot blot (DB)
-
View 2 publications 2 publications
Immunomicroscopy (IM)
-
View 1 publication 1 publication
Miscellaneous PubMed (Misc)
-
View 1 publication 1 publication
Mass Spectrometry (MS)
-
View 1 publication 1 publication
Product Specifications
Species Reactivity
Bovine, Human
Published species
C. elegans, Human, Mouse, Non-human primate, Pig, Rat, Rodent
Host/Isotype
Mouse / IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
HT7
Immunogen
Purified human Tau, epitope human Tau between residue 159 and 163 (numbering according to human Tau40), corresponding to the amino acid sequence PPGQK. if (typeof window.$mangular === undefined
|| !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{
targetFamily:
Tau,
uniProtId:
P10636-1,
ncbiNodeId:
9606,
antigenRange:
159-163,
antigenLength:
758,
antigenImageFileName:
MN1000_Tau_P10636-1_House_mouse.svg,
antigenImageFileNamePDP:
MN1000_Tau_P10636-1_House_mouse_PDP.jpeg,
sortOrder:
1}\]
; $mangular.isB2BCMGT = false
; $mangular.isEpitopesModalImageMultiSizeEnabled = true
;
View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}
Conjugate
Unconjugated Unconjugated Unconjugated
View additional formats
Form
Liquid
Concentration
0.2 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2314654
Product Specific Information
MN1000 recognizes normal Tau from human and bovine brain and PHF-Tau. No cross reactivity with Tau from rat brain has been observed. The epitope of this antibody has been mapped on human Tau between residue 159 and 163 (numbering according to human Tau40), corresponding to the amino acid sequence PPGQK.
MN1000 detects Tau which has a predicted molecular weight of approximately 79 kDa.
Purity is >95% as determined by SDS-PAGE.
Target Information
Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimers diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclin-dependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick
s disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
배송/결제/교환/반품 안내
배송 정보
기본 배송비 |
| 교환/반품 배송비 |
|
---|---|---|---|
착불 배송비 |
| ||
교환/반품 배송비 |
|
결제 및 환불 안내
결제 방법 |
|
---|---|
취소 |
|
반품 |
|
환급 |
|
교환 및 반품 접수
교환 및 반품 접수 기한 |
|
---|---|
교환 및 반품 접수가 가능한 경우 |
|
교환 및 반품 접수가 불가능한 경우 |
|
교환 및 반품 신청
교환 절차 |
|
---|---|
반품 절차 |
|