Thermo Fisher Scientific Tau Monoclonal Antibody (HT7)
인간 및 소 뇌 Tau 단백질을 인식하는 HT7 클론 단일클론 항체로, Western blot, ELISA, IHC 등 다양한 응용에 사용 가능. 인간 Tau 159–163 (PPGQK) 서열에 특이적이며, Alzheimer 연구에 적합. 고순도(>95%), Protein A 정제, PBS 저장.
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Thermo Fisher Scientific Tau Monoclonal Antibody (HT7)
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–5 µg/mL | 112 |
| Immunohistochemistry (IHC) | – | 48 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–10 µg/mL | 6 |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | – | 3 |
| Immunohistochemistry (Frozen) (IHC (F)) | – | 3 |
| Immunohistochemistry – Free Floating (IHC (Free)) | Assay-dependent | 2 |
| Immunocytochemistry (ICC/IF) | – | 22 |
| ELISA | 2–10 µg/mL | 10 |
| Immunoprecipitation (IP) | – | 9 |
| Neutralization (Neu) | – | 1 |
| Functional Assay | – | 2 |
| Dot blot (DB) | – | 2 |
| Immunomicroscopy (IM) | – | 1 |
| Miscellaneous PubMed (Misc) | – | 1 |
| Mass Spectrometry (MS) | – | 1 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Human |
| Published Species | C. elegans, Human, Mouse, Non-human primate, Pig, Rat, Rodent |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HT7 |
| Immunogen | Purified human Tau, epitope between residue 159–163 (PPGQK) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2314654 |
Additional Formats
Product Specific Information
MN1000 recognizes normal Tau from human and bovine brain and PHF-Tau.
No cross-reactivity with Tau from rat brain has been observed.
The epitope is mapped on human Tau between residues 159–163 (PPGQK).
MN1000 detects Tau (~79 kDa predicted molecular weight).
Purity >95% as determined by SDS-PAGE.
Target Information
Tau is a neuronal microtubule-associated protein found predominantly on axons.
It promotes tubulin polymerization and stabilizes microtubules.
The C-terminus binds axonal microtubules, while the N-terminus binds neural plasma membrane components, functioning as a linker between both.
Axonal polarity is determined by TAU/MAPT localization within the neuronal cell body.
Short isoforms allow cytoskeletal plasticity, while longer isoforms contribute to stabilization.
Hyper-phosphorylated Tau forms paired helical filaments (PHF), the major component of neurofibrillary lesions in Alzheimer’s disease.
Phosphorylation impairs microtubule binding, leading to neuronal degeneration.
Kinases involved include GSK-3β, PKA, cdk5, and casein kinase II.
Hyper-phosphorylated Tau is also found in Pick’s disease, frontotemporal dementia, cortico-basal degeneration, and progressive supranuclear palsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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