Thermo Fisher Scientific Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AT8)
AT8 clone의 phospho-Tau (Ser202, Thr205) 단일클론 항체로, 인간 및 마우스 시료 반응성이 검증됨. Western blot, IHC, ICC 등 다양한 응용 가능. PHF-Tau 특이적 인식으로 정상 Tau와 교차 반응 없음. Alzheimer 연구 및 신경퇴행성 질환 연구에 적합.
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Thermo Fisher Scientific Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AT8)
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:250–1:2,000 | View 289 publications |
| Immunohistochemistry (IHC) | – | View 489 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–10 µg/mL | View 43 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | – | View 9 publications |
| Immunohistochemistry - Free Floating (IHC (Free)) | – | View 16 publications |
| Immunocytochemistry (ICC/IF) | 1:50–1:1,000 | View 61 publications |
| Flow Cytometry (Flow) | – | View 4 publications |
| ELISA | – | View 8 publications |
| Immunoprecipitation (IP) | – | View 2 publications |
| in situ PLA (PLA) | – | View 1 publication |
| Dot blot (DB) | – | View 1 publication |
| Inhibition Assays (IA) | – | View 1 publication |
| Immunodiffusion (IDF) | – | View 1 publication |
| Miscellaneous PubMed (Misc) | – | View 21 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | C. elegans, Cat, Chimpanzee, Cynomolgus monkey, Dog, Fruit fly, Hamster, Human, Mouse, Non-human primate, Pig, Rabbit, Rat, Yeast |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AT8 |
| Immunogen | Partially purified human PHF-Tau |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_223647 |
Additional Formats:
Product Specific Information
MN1020 recognizes a phosphatase-sensitive epitope on PHF-Tau.
No cross-reactivity with normal Tau has been observed.
The epitope contains phosphorylated Ser202 and Thr205 residues (numbering according to human Tau40).
MN1020 detects PHF-Tau (Ser202/Thr205), which has a predicted molecular weight of approximately 79 kDa.
This product is a low endotoxin formulation.
Purity is >95% as determined by SDS-PAGE.
Target Information
Tau is a neuronal microtubule-associated protein found predominantly on axons.
It promotes tubulin polymerization and stabilizes microtubules.
The C-terminus binds axonal microtubules, while the N-terminus binds neural plasma membrane components, functioning as a linker between both.
Hyper-phosphorylated Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer’s disease brain.
Phosphorylation impairs Tau’s microtubule binding function, leading to destabilization and neuronal degeneration.
Numerous serine/threonine kinases phosphorylate Tau, including:
- GSK-3β
- Protein kinase A (PKA)
- Cyclin-dependent kinase 5 (cdk5)
- Casein kinase II
Hyper-phosphorylated Tau is found in neurofibrillary lesions in Alzheimer’s disease and other CNS disorders such as:
- Pick’s disease
- Frontotemporal dementia
- Cortico-basal degeneration
- Progressive supranuclear palsy
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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