Thermo Fisher Scientific Human Resistin Recombinant Protein
인간 Resistin 재조합 단백질로, N말단 His-tag을 포함하며 >95% 순도를 가진 액상 시약입니다. 다양한 면역학적 분석에서 양성 대조군으로 사용 가능하며, E. coli 발현 시스템으로 생산되었습니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- RP75711
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Human Resistin Recombinant Protein
Applications
- Western Blot (WB): Assay-dependent
- Control (Ctrl): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Expression System | E. coli |
| Amino acid sequence | Amino acids Ser17–Pro108 containing an N-terminal His-tag |
| Tag | His-tag |
| Class | Recombinant |
| Type | Protein |
| Purity | >95%, by SDS-PAGE under reducing conditions |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.14 mg/mL |
| Purification | Purified |
| Storage buffer | 20 mM Tris HCl, pH 8, with 50% glycerol, 5 mM EDTA |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
Product Specific Information
RP-75711 contains purified recombinant human Resistin protein with an N-terminal hexahistidine tag.
RP-75711 may be used as a positive control in many immunological assays.
Target Information
Adipose tissue functions as an energy reserve and is tightly regulated. Adipocytes produce and secrete numerous physiologically important proteins such as lipoprotein lipase (LPL), leptin, adipocyte complement related protein of 30 kDa (Acrp30), perilipin, and resistin.
Resistin, also known as Adipocyte Secreted Factor (ADSF) and FIZZ3, is a cytokine specifically secreted by adipocytes. Although its function is not fully understood, resistin appears to play key paracrine roles and is suggested to be involved in type 2 diabetes.
Studies have shown that in obese, diabetic mice, serum resistin levels are increased and exert an antagonistic effect on insulin. Additional research indicates resistin contributes to insulin resistance and glucose intolerance in mice.
Resistin gene expression requires C/EBP alpha, which is necessary and sufficient for expression. Coactivators CBP and p300, known for their histone acetyltransferase (HAT) activity, acetylate histones at the resistin promoter, activating chromatin for transcription.
Numerous PPAR gamma and RXR ligands have been shown to downregulate resistin expression in adipocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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