Thermo Fisher Scientific Human Resistin Recombinant Protein

Thermo Fisher Scientific Human Resistin Recombinant Protein

Applications

• Western Blot (WB): Assay-dependent
• Control (Ctrl): Assay-dependent

Product Specifications

Product Specific Information

RP-75711 contains purified recombinant human Resistin protein with an N-terminal hexahistidine tag.
RP-75711 may be used as a positive control in many immunological assays.

Target Information

Adipose tissue functions as an energy reserve and is tightly regulated. Adipocytes produce and secrete numerous physiologically important proteins such as lipoprotein lipase (LPL), leptin, adipocyte complement related protein of 30 kDa (Acrp30), perilipin, and resistin.
Resistin, also known as Adipocyte Secreted Factor (ADSF) and FIZZ3, is a cytokine specifically secreted by adipocytes. Although its function is not fully understood, resistin appears to play key paracrine roles and is suggested to be involved in type 2 diabetes.
Studies have shown that in obese, diabetic mice, serum resistin levels are increased and exert an antagonistic effect on insulin. Additional research indicates resistin contributes to insulin resistance and glucose intolerance in mice.
Resistin gene expression requires C/EBP alpha, which is necessary and sufficient for expression. Coactivators CBP and p300, known for their histone acetyltransferase (HAT) activity, acetylate histones at the resistin promoter, activating chromatin for transcription.
Numerous PPAR gamma and RXR ligands have been shown to downregulate resistin expression in adipocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.