Thermo Fisher Scientific CD47 Monoclonal Antibody (OTI3E10)

Applications

• Flow Cytometry (Flow): 1:100 희석

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

CD47 (integrin-associated protein, IAP) is a ubiquitously expressed transmembrane glycoprotein that interacts with integrins and regulates their functions. Engagement of CD47 modulates signaling pathways, including activation of heterotrimeric G proteins and calcium signaling upon cell adhesion.
It serves as a receptor for the C-terminal domain of thrombospondin and participates in membrane transport and signal transduction. CD47 acts as a ligand for CD172a (SIRPα), preventing phagocytosis of CD47-positive cells and influencing immune regulation, cell migration, and neuronal development, especially in synapse-rich regions of the brain and retina.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.