Thermo Fisher Scientific ABCA5 Polyclonal Antibody
Rabbit polyclonal antibody targeting human ABCA5 protein (aa 1540–1642). Validated for WB and IHC applications. Lyophilized form for research use only. Stable at -20°C; reconstitute in sterile water before use.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | – |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | – |
| Miscellaneous PubMed (Misc) | – | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from aa region 1540–1642 of human ABCA5 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: ABCA5.
Target Information
ABCA5 (ATP-binding cassette, sub-family A (ABC1), member 5) is a 1,642 amino acid protein belonging to the ABC transporter superfamily and the ABCA family. The ABC1 subfamily is exclusive to multicellular eukaryotes. It is ubiquitously expressed, with high expression in testis, skeletal muscle, kidney, liver, and placenta.
ABCA5 is a multi-pass membrane protein containing two ABC transporter domains and exists as three alternatively spliced isoforms. It exhibits membrane subcellular localization and may play a role in processing autolysosomes. Spanning 80 kb, ABCA5 contains 39 exons, with exon 2 containing the putative translation start site.
ABCA5 maps to human chromosome 17q24 and is linked to lysosomal diseases. It may play roles in tumor development, cardiomyocyte and follicular cell activities, and could serve as a specific urine marker for diagnosis of high-grade prostatic intraepithelial neoplasia (HGPIN).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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