Thermo Fisher Scientific ABCA1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:300–1:2,000

Immunohistochemistry (IHC)

• Tested Dilution: 1:300–1:2,000

Miscellaneous PubMed (Misc)

• Publications: View 2 publications

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water.
• Centrifuge to remove any insoluble material.
• The peptide shares 94% identity with mouse and rat sequences.
• Specificity: ABCA1.

Target Information

Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) are associated with Tangier disease (TD), an autosomal recessive disorder characterized by absence of plasma HDL and cholesterol ester deposition in the reticulo-endothelial system.
ABCA1 mediates the apo-A1–associated export of cholesterol and phospholipids from cells. It is expressed on the plasma membrane and Golgi complex, regulated by cholesterol flux.
Regulation of cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.