Thermo Fisher Scientific ABCA1 Polyclonal Antibody
ABCA1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 IHC에 적합합니다. 합성 펩타이드(aa 1200–1300)로부터 유래한 면역원 사용. 동결건조 상태로 제공되며, 4°C 또는 -20°C에서 보관 권장. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from amino acid region 1200–1300 of human ABCA1 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C for short term. For long-term storage, keep at -20°C and avoid freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: ABCA1.
Target Information
Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) are associated with Tangier disease (TD), an autosomal recessive disorder characterized by an absence of plasma HDL and cholesterol ester deposition in the reticulo-endothelial system.
ABCA1 mediates the apoA-I–associated export of cholesterol and phospholipids from cells.
It is expressed on the plasma membrane and Golgi complex, and its expression is regulated by cholesterol flux.
Regulation of cholesterol exchange between HDL and macrophages involves competition between ABCA1 and SR-BI.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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