Thermo Fisher Scientific CD45R Chimeric Recombinant Rabbit Monoclonal Antibody (RA3-6B2)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody specifically recognizes the murine CD45R antigen expressed on B lymphocytes from early pro-B stages through development, and is down-regulated upon differentiation to plasma cells. CD45R is also expressed on a small subset of plasmacytoid dendritic cells. Clone RA3-6B2 recognizes the exon A-restricted isoform of mouse CD45.

Target Information

CD45R (PTPRC) is a member of the protein tyrosine phosphatase (PTP) family involved in regulating cell growth, differentiation, mitotic cycle, and oncogenic transformation. It is expressed in hematopoietic cells and is essential for T- and B-cell antigen receptor signaling. CD45 glycoprotein plays a key role in lymphocyte development and antigen signaling by regulating Src-family kinases. Multiple isoforms exist due to alternative splicing, differing in extracellular domains but sharing identical transmembrane and cytoplasmic domains. CD45 also influences integrin-mediated signaling and apoptosis-related DNA fragmentation. Dysfunction of CD45 is associated with Severe Combined Immunodeficiency and Hepatitis C.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.